Logeart D, Berthelot E, Bihry N, et al. - In patients at high readmission risk at discharge post-treatment for acute heart failure (HF), an intensive follow-up early post-discharge failed to improve outcomes.

• This study included hospitalized acute HF patients with at least one of the following: previous acute HF < 6 months, systolic blood pressure ≤ 110 mmHg, creatininemia ≥180 μmol/L, or BNP ≥350 pg/mL or NTproBNP ≥2200 pg/mL.

• Patients (n=482) were randomly assigned to either optimized care and education with serial consultations with HF specialist and dietician during the first 2–3 weeks, or to standard care after discharge by guidelines.

• Loop diuretics (46%), betablockers (49%), ACE-inhibitors or angiotensin receptors blockers (39%) and mineralocorticoid receptor antagonists (47%) were titrated in the intensive group.

• The occurrence of primary endpoint (all-cause death or first unplanned hospitalization during 6-month follow-up) and mortality at 6 or 12 months or unplanned HF rehospitalization did not differ between the two groups (HR 0.97).

• In addition, no difference by age, previous HF and left ventricular ejection fraction was identified between the two groups.