Skouras S, Torner J, Andersson P, et al. - Researchers conducted the study for identifying the impacts of amyloid-β peptide 42 (amyloid-β₄₂) and phosphorylated tau on the patterns of functional connectomics involved in hippocampal downregulation. Forty-eight cognitively unimpaired participants (22 with elevated CSF amyloid-β peptide 42 levels, 15 with elevated CSF phosphorylated tau levels, mean age of 62.705 ± 4.628 years) were identified, from the population-based ‘Alzheimer’s and Families’ study, with baseline MRI, CSF biomarkers, APOE genotyping and neuropsychological evaluation. Comparable eigenvector centrality patterns in the cingulate had previously been linked to CSF biomarkers in mild cognitive impairment and dementia individuals during resting state functional MRI. The non-invasive, interactive, adaptive and gamified neuroimaging procedure can provide relevant information for clinical prognosis and monitoring of therapeutic effectiveness in the absence of CSF biomarkers. To promote replication studies, they have released the developed paradigm and analysis pipeline as open-source software.