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Earlier time to hemostasis is associated with decreased mortality and rate of complications: Results from the Pragmatic Randomized Optimal Platelet and Plasma Ratio trial

The Journal of Trauma and Acute Care Surgery Aug 03, 2019

Chang R, Kerby J, Kalkwarf KJ, et al. - As the faster time to hemostasis is recognized as significant in bleeding trauma patients by clinicians, researchers sought to report on these times. From the Pragmatic Randomized Optimal Platelet and Plasma Ratios trial, data were prospectively collected and analyzed. No intraoperative bleeding requiring intervention in the surgical field or resolution of contrast blush on interventional radiology was defined as hemostasis. They included 680 patients; of these, 468 (69%) underwent an emergent procedure. They observed a reduced incidence of 30-day mortality, acute kidney injury, acute respiratory distress syndrome, multiple-organ failure, and sepsis in bleeding trauma patients in correlation with every 15-minute decrease in time to hemostasis. They recommend considering the time to hemostasis as an endpoint in trauma studies and as a potential quality indicator.
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