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Dysregulation of circulating miR-24-3p in children with obesity and its predictive value for metabolic syndrome

Obesity Facts Aug 27, 2021

Zhang B, Xing L, Wang B, et al. - MiR-24-3p not only affords a potential noninvasive marker for children with obesity but also demonstrated its predictive value for the development of metabolic syndrome.

  • This study involved children with obesity (n = 45), obese children with metabolic syndrome (n = 52), and healthy controls (n = 50).

  • Via reverse transcription quantitative PCR, expression levels of miR-24-3p were measured.

  • Obese children with metabolic syndrome had the highest expression of miR-24-3p.

  • miR-24-3p enabled differentiation between healthy individuals and obese children (area under the curve [AUC] = 0.951).

  • miR-24-3p predicted metabolic syndrome occurrence for obese children (AUC = 0.890).

  • miR-24-3p expression level had positive correlation with body mass index, fasting blood glucose, triglycerides, systolic blood pressure, and diastolic blood pressure.

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