Dysbiosis of the endometrial microbiota and its association with inflammatory cytokines in endometrial cancer
International Journal of Cancer Dec 11, 2020
Lu W, He F, Lin Z, et al. - Researchers sought to determine the composition of the endometrial microbiota as well as the link with inflammatory cytokines in endometrial cancer (EC). Via 16S ribosomal RNA gene amplicon sequencing, experts evaluated endometrial microbiota profiles of women with EC (n = 25) and benign uterine lesions (BUL, n = 25). At the genus level, more abundance of Micrococcus in the EC group was evident. Enrichment of Pseudoramibacter_Eubacterium, Rhodobacter, Vogesella, Bilophila, Rheinheimera, and Megamonas was found in the BUL group. Except for interleukin‐6 (IL‐6) protein levels, both groups had no different interleukin‐8(IL‐8) and interleukin‐17(IL‐17) protein levels. There was a significant difference in mRNA expression levels of IL‐6, IL‐8, and IL‐17. Moreover, positive correlation of the relative abundances of Micrococcus with IL‐6, and IL‐17 mRNA levels was identified. Overall, dysbiosis of endometrial microbiota and the inflammatory cytokines were found to be related to Micrococcus in patients suffering from endometrial cancer.
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