Eroglu S, et al. - Analysts measure and compare the dynamic thiol and disulphide homeostasis between patients with Uterine Myoma (UM) and healthy subjects. In this study, they observed that the native thiol, total thiol, and disulphide levels in patients with UM reduced while the ratio of native thiol/disulphide remained unchanged. It is essential to explore whether these findings have a role in the etiology and clinical course of the UM.

Methods

• Patients with UM who were diagnosed by transvaginal ultrasonography and 37 age- and body mass index-matched healthy individuals were incorporated into this study.
• A total of 54 patients were enrolled in this study.
• Thiol/disulphide homeostasis was measured by a novel automatic spectrophotometric method.

Results

• The observed the mean serum native thiol, disulphide, and thiol levels were statistically lower in UM group than those in the control group [(284.66 ± 59.41 μmol/L vs. 320.98 ± 56.17 μmol/L, P < 0.0001) and (319.21 ± 61.69 vs. 365.76 ± 61.46 μmol/L, P < 0.0001), respectively].
• No statistically important differences was seen in ratios of the disulphide/native thiol, native thiol/total thiol, and disulphide/total thiol among patients with UM versus healthy control group (P = 0.096, 0.092, 0.092, respectively).