Gkontra P, et al. - In order to better understand changes in cardiac tissue perfusion post-myocardial infarction (MI), researchers attempted to model blood flow properties in coronary microcirculation at various time points following MI and compared them with healthy conditions. They created an image-based modeling framework that allowed feeding a continuum flow model with anatomical data collected earlier from the pig coronary microvasculature. This enabled estimation of physiologically significant permeability tensors, which included the microvascular conductivity. On days 1 and 7 post-MI, a bimodal pattern of increase in tensors at infarcted areas was detected; a nonphysiological decrease in arteriole–venule drop in pressure; conversely, the tensors and the arteriole–venule fall in pressure on day 3 post-MI, and in remote areas, were closer to values for healthy tissue. In infarcted areas, a decrease in myocardial blood flow (calculated using the condition-dependent arteriole–venule drop in pressure) was noted.