Duration of type 2 diabetes mellitus and systolic blood pressure as determinants of severity of coronary stenosis and adverse events in an asymptomatic diabetic population: PROCEED study
Cardiovascular Diabetology Apr 27, 2019
Venuraju SM, et al. - In 259 patients with type 2 diabetes mellitus (T2DM) recruited from clinics in Northwest London, United Kingdom, researchers investigated if significant coronary artery disease (CAD) could be predicted by clinical and demographic features. Study participants underwent computed tomography coronary angiography (CTCA) and laboratory assessments. Significant predictors of cardiovascular adverse events, identified in multivariate analyses, included duration of diabetes, coronary artery calcium score, the presence and number of coronary artery plaques, and the presence of significant plaque. Significant CAD was predicted by the duration of diabetes of > 10.5 years in a receiver operating characteristic curve (ROC) analysis. The area under the ROC curve was 0.67 when duration of T2DM of > 10.5 years and systolic blood pressure of > 139 mmHg were combined. Overall, for patients with T2DM for > 10.5 years and SBP level of > 140 mmHg, the investigators recommended routine screening for CAD using CTCA.
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