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Duration of post-operative hypocortisolism predicts sustained remission after pituitary surgery for Cushing's disease

Endocrine Connections Sep 24, 2017

Bansal PAK, et al. - The post-operative remission and long-term recurrence rates, as well as their respective predictive factors were investigated. The authors found similar remission and recurrence rates to that of reported literature, but the proportion of delayed remission was relatively higher. Negative/equivocal MRI findings and presence of macro-adenoma were predictors of poor remission rates, particularly those with cavernous sinus invasion. Longer duration of post-operative hypocortisolism was an important predictor of sustained remission in addition to early remission. Regular biochemical surveillance could help in identifying recurrence early.
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