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Duration of mechanical ventilation and extubation success among extremely premature infants

Neonatology Feb 26, 2021

Ohnstad MO, Stensvold HJ, Tvedt CR, et al. - Researchers undertook this population-based study to determine the span of mechanical ventilation (MV) in days until the first successful extubation as well as the cumulative span of MV until discharge of infants with gestational age (GA) < 26 weeks. Additionally, they investigated links between early clinical variables and the cumulative duration of MV. Data from the Norwegian Neonatal Network were obtained for extremely premature infants admitted between January 1, 2013, and December 31, 2018. According to the findings, successful extubation at the first attempt was achieved in most of the infants born at GA 25 weeks. However, there were unsuccessful extubations in half of the infants born < 26 weeks, suggesting that useful clinical predictors of successful extubation are lacking. Among survivors, 4 weeks longer median duration of MV was noted for infants at GA 22–23 weeks vs those born at GA 25 weeks, while the variation in median postmenstrual age at the first successful extubation was identified to be 2 weeks.

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