Hauser RA, Zeitlin L, Fisher S, et al. - Researchers sought to determine the mean duration of ON time per dose and mean duration of ON time without troublesome dyskinesia per dose of carbidopa-levodopa (CD-LD) immediate release (IR) vs CD-LD extended release capsules (CD-LD ER, Rytary) in the ADVANCE-PD trial. Data reported that the mean (SD) baseline ON time per dose of CD-LD IR (n = 393) was 2.20 h. CD-LD ER significantly increased ON time per dose compared with CD-LD IR (+1.21 h) in the ADVANCE-PD trial and provided significantly more ON time per dose (3.55 h vs 2.38 h).