Heilmann E, Gregoriano C, Annane D, et al. - An individual patient data meta-analysis was conducted to evaluate the relationship of age on effects of procalcitonin (PCT)-guided antibiotic stewardship regarding antibiotic use and outcome. Researchers examined a total of 9,421 individual infection patients from 28 randomized controlled trials comparing PCT-guided antibiotic therapy (intervention group) or standard care. The primary outcome included the duration of antibiotic treatment and 30-day mortality and length of stay were considered as secondary outcomes. This study’s findings demonstrate that similar to younger patients, PCT-guided antibiotic treatment in older patients is correlated with significantly decreased antibiotic exposures and no increase in mortality.