Zhong D, Xiao S, Debes AK, et al. - SARS-CoV-2 spike IgG antibodies were examined in a longitudinal cohort of individuals who received an mRNA SARS-CoV-2 vaccine with or without prior SARS-CoV-2 infection in order to compare antibody durability among these individuals.

• A convenience sample of 3,500 healthcare workers from the Johns Hopkins Health System provided serum samples longitudinally, separated by at least 90 days.

• Collection of serum samples from included participants was done at least 14 days after receiving the second dose of an mRNA SARS-CoV-2 vaccine.

• Analysis revealed higher spike antibody measurements among healthcare workers with prior SARS-CoV-2 infection followed by 2 doses of mRNA vaccine (3 independent exposures to spike antigen) vs individuals with vaccination alone.

• In line with work comparing extended vaccine dosing intervals, the study indicated that the antibody response may increase with a longer interval between infection and first vaccine dose.