Hu X, Gu Q, Zhang K, et al. - Whether application of dual-energy computed tomography is feasible for detecting mediastinal lymph node (LN) metastasis in patients suffering from lung cancer, was investigated in this retrospective analysis. Researchers collected 74 mediastinal LNs, including 33 metastatic LNs and 41 nonmetastatic LNs. They found that the most favorable biomarker for detecting mediastinal LN metastasis was the attenuation value at 40 keV (area under curve, 0.91; sensitivity, 0.94; specificity, 0.81), which displayed a much better performance in comparison to the LN diameter-based assessment method (area under curve, 0.72; sensitivity, 0.66; specificity, 0.82; net reclassification improvement, 0.359; integrated discrimination improvement, 0.330). Findings demonstrate a promising worth of dual-energy computed tomography as a diagnostic tool for the diagnosis of mediastinal LN metastasis in patients suffering from lung cancer. This tool may provide assistance to clinicians in implementing personalized therapeutic strategies.