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Dual antiplatelet therapy with clopidogrel and aspirin vs aspirin monotherapy in patients undergoing coronary artery bypass graft surgery

Journal of the American Heart Association May 19, 2021

Qu J, Zhang H, Rao C, et al. - Researchers examined the link of dual antiplatelet therapy (DAPT) with clopidogrel plus aspirin and clinical results in patients receiving coronary artery bypass grafting. Participants were 18,069 patients who had primary isolated coronary artery bypass grafting between 2013 and 2017, and 10,854 (60.1%) were treated with DAPT with clopidogrel plus aspirin as ascertained via claimed prescriptions post-surgery. A decreased risk of major adverse cardiovascular and cerebrovascular events within 6 months was shown to be conferred by DAPT with clopidogrel plus aspirin as secondary prevention, vs aspirin monotherapy, without significantly increasing major bleeding in patients undergoing coronary artery bypass grafting.

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