Costa F, et al. - Researchers assessed clinical outcomes of complex percutaneous coronary intervention (PCI) in relation to ischemic (by PCI complexity) and bleeding (by PRECISE-DAPT score) risks. They also determined the effect of these risks on the influence of dual antiplatelet therapy (DAPT) duration after coronary stenting. Overall, 14,963 patients from 8 randomized trials were identified; of these, complex PCI was performed on 3,118 who experienced a higher rate of ischemic, but not bleeding, events. On the basis of randomly allocated duration of DAPT, they assessed ischemic and bleeding outcomes in high (≥ 25) or non-high (< 25) PRECISE-DAPT strata. A higher risk of ischemic events was noted among patients who had complex PCI. These patients, in the absence of HBR features, benefitted from long-term DAPT. According to findings, when concordant, bleeding, more than ischemic risk, should inform decision-making on DAPT duration.