Dual antiplatelet therapy and surgical timing in geriatric hip fracture
Journal of Orthopaedic Trauma Sep 28, 2020
Tarrant SM, Kim RG, McGregor KL, et al. - Researchers performed a retrospective cohort study examining the effect of timing of surgery on transfusion, major complications, and mortality in patients who sustain a geriatric hip fracture while taking dual antiplatelet therapy (DAPT; typically aspirin and clopidogrel). Among the 6,724 patients sustaining a geriatric hip fracture, 122 patients reported taking DAPT on admission. The patients received fixation or arthroplasty. No effect of timing of surgery on transfused units was evident but it was noted affecting major complications (time modeled as quadratic term; odds ratios ranging from 0.20 to 7.91, ptime = 0.001, ptime*time < 0.001) and 30-day mortality (odds ratio 1.32, 95% confidence interval: 1.03–1.68, P = 0.030). Based on findings, timing of surgery is linked with raised probabilities of major complications and 30-day mortality.
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