Man SLP, et al. - Researchers compared the treatment profiles of methotrexate and cyclosporine in daily practice as the first-line immunosuppressive treatment in atopic dermatitis, using two survival analyses, ‘drug survival’ (time on the drug) and ‘postdrug survival’ (time between two drugs). Between methotrexate and cyclosporine as first-line immunosuppressive treatments for moderate-to-severe atopic dermatitis in daily practice, this was the first direct comparison. Two different treatment profiles were evidenced: The duration of methotrexate administration is longer than that of cyclosporine. To assess the maintenance of effect of a drug after withdrawal in atopic dermatitis, and more broadly in chronic skin disease, 'postdrug survival’ could be a new tool.