Drug resistance of previously treated tuberculosis patients with diabetes mellitus in Shandong, China
Respiratory Medicine Feb 16, 2020
Song WM, Li YF, Liu JY, et al. - In this observational analysis including 1,791 retreated tuberculosis (TB)-no diabetes mellitus (DM) patients (refers to TB cases without diabetes) and 93 retreated TB-DM patients (refers to TB cases with diabetes), researchers examined the association between diabetes and drug resistance among previously treated TB patients. This inquiry was undertaken in Shandong, China. A significant link of diabetes co-morbidity with any drug-resistant tuberculosis, multidrug resistant tuberculosis, isoniazid-related resistance, rifampin-related resistance, isoniazid + rifampin resistance, any resistance to isoniazid + streptomycin, and any resistance to rifampin + isoniazid, was reported vs pan susceptible TB cases. Among retreated TB-DM patients vs retreated TB-no DM patients, findings revealed that the risk of acquired drug resistance increased significantly, this indicates the need for more interventions during the clinical management of TB-DM cases.
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