Wilson MN, et al. - Whether youth who use alcohol mixed with energy drinks (AmED) were more likely to engage in driving, or being a passenger of a driver, under the influence of alcohol or cannabis compared to youth who use either alcohol or energy drinks alone, was investigated using data from grade 10–12 students who took part in the 2014/2015 Canadian Student Tobacco, Alcohol and Drugs Survey and logistic regression. In the past 12 months, AmED consumption was reported by one in four youth. Relative to youth who used alcohol alone, a higher risk profile for driving under the influence of alcohol or cannabis was shown by youth who used AmED.