Liu Y, et al. - Considering the correlation of regulatory factor X1 (RFX1) deletion with poor prognosis of some types of cancer, researchers assessed the prognostic value of RFX1 in HCC, especially in small hepatocellular carcinoma. They used immunohistochemical assay to investigate RFX1 expression in 221 HCC tissues and another validation cohort of 71 small HCC samples. They identified RFX1 downregulation to be a new predictive marker of high recurrence risk and poor prognosis of HCC. It could have utility for guiding treatment for postoperative HCC patients, especially for small HCC patients.