Chen YJ, et al. - Since previous studies have shown that microRNA-144-3p (miR-144-3p) could have potential as a biomarker in non-small cell lung cancer (NSCLC), researchers explored the mechanism behind the effects of miR-144-3p on the origin, differentiation, and apoptosis of NSCLC, as well as the relationship between miR-144-3p and clinical parameters. Findings of this meta-analysis suggested a significant association of miR-144-3p expression with stage, lymph node metastasis and vascular invasion. The current study validated the low expression of miR-144-3p in NSCLC. Most importantly, miR-144-3p may function in the NSCLC prognosis prediction as a latent tumor biomarker. Bioinformatics analytical results may present a new method for investigating NSCLC pathogenesis.