Zhang D, Yang XJ, Luo QD, et al. - Researchers investigated the involvement of a novel circular RNAs (circRNAs) circ_000926 in renal cell carcinoma (RCC), and how it affects tumorigenesis. Employing microarray-based circRNA/gene expression profiling of RCC, differential expression of circRNAs/genes in RCC and normal tissues was determined. RCC tissues and cell lines showed high expression of circ_000926, whereby CDH2 was verified as a target of miR-411. circ_000926, as a ceRNA, could bind directly to miR-411 to up-regulate CDH2. They noted inhibition of growth, migration, and invasion abilities of RCC cells, as well as suppression of EMT and tumor growth following down-regulation of circ_000926. However, the anti-tumor effects induced by silencing circ_000926 were reversed when the miR-411 inhibited or CDH2 increased. Altogether, these findings suggest an inhibitory effect of down-regulation of circ_000926 on RCC progression via miR-411–dependent CDH2 inhibition, highlighting it as a potential target for RCC treatment.