Gabriel IM, et al. - Researchers estimated the link between douching and/or talc use and risk for epithelial ovarian cancer (EOC), using unconditional logistic regression and by analyzing 2,040 cases of EOC and 2,100 controls registered in eastern Massachusetts and New Hampshire. They also examined subsets of cases and controls to estimate risk for pelvic inflammatory disease (PID), ectopic pregnancy, and cervical neoplasia resulting from douching and/or talc use. For all EOC, the adjusted OR and 95% CI of 0.94 (0.76–1.16) and 1.28 (1.09–1.51) was reported in women who douched but never used talc and for those who used talc but never douched, respectively. For women who both used talc and homemade douches and for women who both used talc and store-bought douches, the estimated ORs (95% CIs) were 0.83 (0.52–1.33) and 1.53 (1.11–2.10), respectively, when compared with women who never regularly douched or used talc. The likelihood of developing PID was more in those who both douched and used talc vs those who had used neither. Overall, douching did not confer an independent risk for ovarian cancer, but a modest increase in the risk for EOC may be seen in correlation with the combination of talc use and store-bought douches, beyond that noted for talc use alone.