Hamstra DA, et al. - Researchers tested whether oral D-methionine (D-met) reduced mucositis during chemoradiotherapy for head and neck cancer. They performed a placebo-controlled double-blind randomized phase II trial of D-met testing the rate of severe mucositis. On multiple assessments, authors noted that mucositis was decreased with D-met, although the primary endpoint was not met. Decreased oral ulceration and erythema was seen with D-met on planned secondary analysis of a semiquantitative scoring system.