Dose-response relationship between gamma-glutamyltransferase and the risk of atherosclerotic cardiovascular diseases in Korean adults
Atherosclerosis Nov 25, 2019
Jeon J, et al. - Researchers performed this observational study with 419,433 people in order to determine if serum gamma-glutamyltransferase (GGT) value has an independent link and dose-response link with the risk of atherosclerotic cardiovascular disease (ASCVD). The participants were selected from the National Health Insurance Service database. The categorization of serum GGT levels into gender-specific quartiles was done. A 4,572,993.8 person-years of follow-up was performed for ASCVD, during which, 40,359 (9.6%) incident cases of ASCVD were reported. A significantly higher risk for incident hemorrhagic stroke was observed in serum GGT quartile groups 2, 3, and 4 vs the serum GGT quartile group 1. Findings revealed a strong independent link and dose-response association of serum GGT value (which is acknowledged as a factor connected to cardiovascular diseases) with hemorrhagic stroke risk vs that with ischemic stroke or ischemic heart disease.
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