Laprie A, et al. - Given that local relapses, mostly occurring in the irradiation field lowers the benefits of external beam radiotherapy (EBRT) regarding the overall survival among cases with glioblastoma and that the ratio of spectra of choline/N acetyl aspartate> 2 (CNR2) on MR spectroscopic imaging predicts the site of local relapse, researchers sought to investigate if dose escalation on these regions would increase local control and hence global survival in this multicenter prospective phase III trial. Randomization of 220 newly diagnosed glioblastoma patients having undergone biopsy or surgery to two arms is done: Arm A is the Stupp protocol (EBRT 60 Gy on contrast enhancement + 2 cm margin with concomitant temozolomide (TMZ) and 6 months of TMZ maintenance); Arm B is the same treatment with an additional simultaneous integrated boost of intensity-modulated radiotherapy (IMRT) of 72Gy/2.4Gy delivered on the MR spectroscopic imaging metabolic volumes of choline (Cho)\N-acetyl-aspartate (NAA)  > 2 and contrast-enhancing lesions or resection cavity. Overall survival is the principal endpoint. In the experimental arm, they performed online prospective quality control of volumes and dose. A large amount of longitudinal multimodal MR imaging data including planning CT, radiotherapy dosimetry, MR spectroscopic, diffusion and perfusion imaging, will be yielded by this work.