Liang HL - Sixty healthy individuals were involved in order to predict the blood volume flow of the lower extremities by means of Doppler method, to build a quantitative association between volume flow and pulsatility index (PI) in both healthy individuals and patients with peripheral artery disease (PAD), and to derive arterial blood flow equations in the lower extremities for more precise volume flow estimations. In the common femoral artery, superficial femoral artery, popliteal artery, dorsalis pedis artery, and common plantar artery, volume flow was 434.4 mL/min, 172.5 mL/min, 92.1 mL/min, 11.8 mL/min, 12.0 mL/min, respectively. Between the reciprocal of PI and volume flow, linear relationships were obtained and revealed as linear blood flow equations. For the persons with PAD, no statistical rise in measured flow in the downstream artery following percutaneous angioplasty was discovered, however, the reduced flow was noted in four arteries. Following normalization of flow measurements with PI values, nevertheless, among percentage increment calculations, statistical advances were seen. Hence, when real-time PI values are factored into blood volume flow calculations in the assessment of lower extremity arteries, discrepancies in flow measurements could be solved, leading to more reliable and stable measurements of clinical and diagnostic importance.