Liu L, et al. - In this systematic review and network meta-analysis, researchers discovered the potential impact of the weekend effect [weekend admissions are consistently related to worse patient outcomes vs weekday admissions, known as the “weekend effect”] on primary (ie, mortality) and secondary outcomes of patients with upper gastrointestinal hemorrhage (UGIH). A total of 25 studies were eligible, including 28 analyses (n = 1,203,202 individuals). The findings showed a trend toward increased 30-day mortality and increased in-hospital mortality among weekend admissions. Significance differences were noted in mortality according to the study location (ie, Europe) and UGIH type (ie, variceal UGIH) in a subgroup analysis, with these subgroups having raised mortality rates. In addition, admissions on weekdays were related to a significant reduction in rebleeding rates. The idea that weekend admissions were linked to an increased risk of death was supported, particularly among variceal UGIH patients in European hospitals.