Does the pretransplant use of statins in recipients have a role in the incidence of primary graft dysfunction after lung transplantation? R-ESTAcitos: Multicenter clinical study
The Journal of Heart and Lung Transplantation Apr 04, 2020
Bello I, Sandiumenge A, Coll E, et al. - In view of the immunomodulatory and antiinflamatory effects of statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, researchers here examined if incidence of primary graft dysfunction (PGD) after lung transplant (LT) decreases in correlation with recipient's preoperative statin therapy. In this multicenter retrospective analysis, 474 adult LT recipients were reviewed. Of these, 110 were on statin treatment. PGD developed in a total of 161 patients (34%), without significant differences between groups (32.2% vs 39%). Outcomes, however, revealed reduced severity of PGD in those on statin treatment.
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