Ferguson I, et al. - Researchers analyzed the evidence reporting post-anaesthesia induction haemodynamics, intubating conditions and mortality in relation to adding fentanyl to an induction regime of ketamine and a paralysing agent. They searched the Cochrane library, EMBASE, MEDLINE, PROQUEST, OpenGrey and clinical trial registries and identified studies related to intubation of adult patients in the prehospital or emergency department environments and included an induction regime of ketamine and a paralysing agent, with at least one outcome measure of haemodynamics, intubating conditions or mortality. They found only one observational study that answered the research question partially. An increased incidence of post-induction hypotension, a phenomenon that was seen with propofol, midazolam and ketamine, was noted in association with the use of fentanyl as a pretreatment. No statistically significant difference in hypotension was evident between these agents. No clarity was gained regarding the effect of this on patient-orientated outcomes.