Chowdhary M, et al. - Using The National Cancer Data Base, researchers determined how overall survival (OS) of patients with high-risk extremity/trunk soft-tissue sarcoma (ET-STS) is influenced by integrating chemotherapy with neoadjuvant radiotherapy (RT). Stratification of adult patients with high-risk ET-STS managed with neoadjuvant RT and limb salvage surgery was done into RT and chemoradiotherapy (CRT) cohorts. Of 884 patients in total, 639 (72.3%) were allocated in the RT cohort and 245 (27.7%) in the CRT cohort. A significantly higher unadjusted 5-year Kaplan-Meier OS rate was found in the CRT cohort. In univariate and multivariable analyses, a link was identified between neoadjuvant chemotherapy and improved OS. Among participants, an improved OS was achieved with the addition of chemotherapy to neoadjuvant RT.