Huang ZH, et al. - Using data from the 2000–2010 Taiwan National Health Insurance Research Database, a nationwide retrospective observational study was conducted to examine the connection between nephrotic syndrome (NS) and Parkinson’s disease (PD) and secondary parkinsonism (sPS). Participants in the study were 3,663 patients with NS and 14,652 randomly selected, age-matched and sex-matched patients without NS. Results of this study suggested that patients with NS had an increased risk of PD and sPS, which could be related to brain vascular damage or blood-brain barrier impairment.