Chisholm AG, et al. - In this retrospective cohort study, researchers desired to know whether the addition of intraoperative intravenous acetaminophen reduces perioperative morphine use in pediatric tonsillectomy. This research was conducted at a tertiary care academic children's hospital. Participants in the study were 166 pediatric patients, aged 1 to 16 years, who had tonsillectomy with or without adenoidectomy. Seventy-four individuals were treated with intraoperative intravenous acetaminophen (intervention cohort), whereas 92 patients did not receive any intraoperative intravenous acetaminophen served as the control. In either group of the postanesthesia care unit, there was no adverse respiratory event (oxygen desaturation < 92% lasting more than a minute, requiring bag mask ventilation or reintubation). Results of this study suggested that intraoperative use of intravenous acetaminophen in pediatric tonsillectomy may lessen the use of opioid perioperatively for ideal pain management.