Chisholm AG, et al. - This retrospective cohort study was undertaken to determine whether the addition of intraoperative intravenous acetaminophen reduces perioperative morphine use in pediatric tonsillectomy. This investigation was carried out at a tertiary care academic children's hospital. The study sample consisted of 166 pediatric patients, aged 1 to 16 years, who had tonsillectomy with or without adenoidectomy. Seventy-four patients were treated with intraoperative intravenous acetaminophen (intervention cohort), while 92 patients did not receive any intraoperative intravenous acetaminophen served as the control. According to findings, intraoperative use of intravenous acetaminophen in pediatric tonsillectomy may lessen the use of opioid perioperatively for ideal pain management. In either group of the postanesthesia care unit, there was no adverse respiratory event (oxygen desaturation < 92% lasting more than a minute, requiring bag mask ventilation or reintubation).