Nejati A, et al. - Researchers investigated the efficacy of intramuscular ondansetron on ketamine-associated vomiting in children undergoing procedural sedation. They conducted a randomized, double-blind, placebo-controlled, parallel-group clinical trial including children (6-month to 16-year-old) who received IM ketamine for PSA in the emergency department. Either ketamine 4 mg/kg or ketamine 4 mg/kg plus ondansetron 0.1 mg/kg was administered intramuscularly to the participants. Ondansetron plus ketamine was administered to 56 patients and the control group was comprised of 65 patients. Outcomes support the efficacy of intramuscular ondansetron in controlling ketamine-associated vomiting.