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Does intensity-modulated radiation therapy lower the risk of osteoradionecrosis of the jaw? A long-term comparative analysis

International Journal of Oral & Maxillofacial Surgery Jun 27, 2019

Willaert R, et al. - Via evaluating medical files and radiological images of 109 patients treated with primary intensity-modulated radiation therapy (IMRT) and 129 patients treated with primary three-dimensional conformal radiotherapy, researchers examined the effect of different radiation techniques on the long-term incidence of osteoradionecrosis in head and neck cancer. In a retrospective, comparative, observational study, risk factors and the occurrence of osteoradionecrosis were analyzed. During a mean follow-up of 4.3 years, 22 patients developed osteoradionecrosis. Multivariate analysis exhibited evidence of a higher risk of osteoradionecrosis in patients with an oropharynx tumour and after radiation therapy in patients with a tooth extraction. Although the incidence of osteoradionecrosis tended to be lower after IMRT, it remains a serious problem due to multifactorial aetiology and cannot be prevented by new techniques of radiotherapy. In order to control additional risk factors and prevent osteoradionecrosis, continuous attempts are required.
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