Nguyen P, et al. - Surgical resection for locally advanced rectal adenocarcinoma commonly occurs 6 to 10 weeks after completion of neoadjuvant chemoradiation (nCRT). In this retrospective analysis, researchers intended to determine the optimal timing of surgery related to the pathologic complete response rate and survival endpoints. An increased risk of distant failure (DF) was reported in association with delaying surgical resection longer than 8 weeks after nCRT. The recent trend in promoting surgical delay beyond the traditional 6 to 10 weeks was questioned by the findings of this study, in combination with a recent larger study.