Tesema G, et al. - Using databases of PubMed, Science Direct, SPORTDiscus, Google Scholar and grey literatures with Mesh and free-text search as well as manual searches, researchers analyzed the impacts of high-intensity chronic endurance training on cardiovascular markers of active populations and athletes. The authors discovered that chronic high-intensity endurance training improves healthy lipid profiles ie, increase high-density lipoprotein, decreased low-density lipoprotein and total cholesterol. And reduced inflammatory markers (IL-6 and CRP) regardless of age and gender and cannot be related to an increased risk of developing cardiovascular disease.