Peyronnet V, et al. - Researchers analyzed 7079 pregnancies in women with HIV-1 infection from the national multicenter prospective French Perinatal cohort at 14 week gestation or more to determine the virological outcomes in correlation to changing antiretroviral therapy (ART) during pregnancy because of concern about fetal risks. Reception of ART was reported in 1797 at conception with a viral load <50 copies/mL before 14 week gestation. Regimens were changed in 22 in the first trimester for intolerance, and 411 (23%) for safety concerns. Outcomes revealed no destabilizing effect on viral suppression with respect to changing ART early in pregnancy to regimens considered safer for pregnancy and neonatal health.