Uchino M, Ikeuchi H, Hata K, et al. - Researchers assessed the efficacy of anti‐TNF therapy after stratification by the outcome of interest and the adverse events (AEs) in this systematic review and meta‐analysis. They explored anti‐TNF therapy, Crohn's disease (CD), and postoperative recurrence with the literature review and endoscopic and clinical recurrence and adverse events (AEs) via a meta‐analyses. The study included eight studies including a population that consisted of 570 participants, with 254 patients in the intervention group and 316 patients in the control group. For CD, anti‐TNF therapy following surgery is effective in preventing endoscopic recurrence for 1–2 years, with no increase in the incidence of AEs, but clinical recurrence was not significantly lowered. The effectiveness of postoperative anti‐TNF therapy may differ in terms of the outcomes, which include long‐term prevention, the avoidance of further surgery, and cost‐effectiveness.