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Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study

Cancer Medicine Feb 16, 2019

Liu J, et al. - Using a Mendelian randomization (MR) approach, researchers investigated the causal impact of docosapentaenoic acid (DPA) on lung cancer. The summary data from the Cohorts for Heart and Aging Research in Genomic Epidemiology (8,866 individuals of European ancestry) Consortium and the International Lung Cancer Consortium (11,348 lung cancer patients and 15,861 controls—all of European ancestry) were analyzed using a two-sample MR approach. According to findings, a positive association of genetically predicted higher DPA level with lung cancer was observed, where a 2.01-fold risk of lung cancer was noted in association with 1% higher DPA. Findings also revealed that lung cancer was not a causal factor for DPA.

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