Steiner N, Ruiter-Ligeti J, Frank R, et al. - The success of ovulation induction using oral agents vs gonadotropins (GTs) was determined in women ≥ 38 years old. In this retrospective cohort study, researchers included all first to third stimulated IUI cycles performed after the age of 38 years in a single academic fertility center between January 2011 and March 2018. Of 1,596 included IUI cycles, 240 cycles were with clomiphene citrate (CC), 176 were letrozole cycles and 1,180 were gonadotropin (GTs) cycles. The 3-groups exhibited no difference in pregnancy or clinical pregnancy rates after controlling for confounders. Relative to GTs, oral agents incurred lower costs and are more patient friendly, hence, oral agents should be first line for ovarian stimulation and IUI in women 38-43-years of age.