Kidoguchi M, et al. - Researchers gauged the methylation levels in the proximal tissue-type plasminogen activator (PLAT) promoter and their effects on gene expression in nasal polyps (NP) tissue. In NP, the gene expression may be downregulated by hypermethylation of PLAT promoter, thereby, leading to excessive fibrin deposition by aberrant coagulation cascade. Findings suggested a probable contribution of DNA methylation of proximal PLAT promoter to NP growth and it may have a potential as a new therapeutic target.