Forno E, et al. - In 483 Puerto Rican children aged 9–20 years, a genome-wide study of DNA methylation was done in nasal epithelium and atopy or atopic asthma to examine DNA methylation profiles that are associated with—and could accurately classify—atopy and atopic asthma in school-aged children. Children with (n=312) and without (n=171) atopy showed marked differences in DNA methylation profiles. Researchers identified a nasal methylation panel that could classify children by atopy or atopic asthma. These findings support that nasal methylome could be used for future clinical applications, such as predicting the development of asthma among wheezing infants.