Koroknai V, Szász I, Hernandez-Vargas H, et al. - As cancer-related gene methylation plays a fundamental role during tumorigenesis and can contribute to cellular plasticity that facilitates invasion, researchers identified novel epigenetic markers on selected invasive melanoma cells. They examined the DNA methylation landscape of selected invasive melanoma cells and studied the effect of DNA methylation on gene expression patterns using Illumina BeadChip assays and Affymetrix Human Gene 1.0 microarrays. Several methylation changes that can play a role during melanoma progression were identified, involving hypermethylation of the promoter regions of the ARHGAP22 and NAV2 genes that are commonly altered in locally invasive primary melanomas and during metastasis. Interestingly, the down-regulation of the methylcytosine dioxygenase TET2 gene, which regulates DNA methylation, was linked to hypermethylated promoter region of the gene. This may likely lead to the observed global trend of invasive cells being hypermethylated and may be one of the key changes during malignant melanoma cells development.