Narasimhaiah D, et al. - Using transcriptomic profiling (n = 15), reverse transcription polymerase chain reaction (n = 36), immunohistochemistry (n = 89), Multiplex Ligation-dependent Probe Amplification (MLPA) for copy number alterations (CNA) analysis (n = 89), array-comparative genomic hybridization (n = 17), and survival statistics (n = 86), researchers analyzed primary, untreated, and mainly large uveal melanomas with retinal detachment in order to define the biological characteristics of intra-tumor immune population in uveal melanomas. Further, they compare it to other established biomarkers and to patients' outcome. Observations revealed a subset of uveal melanomas in which high degree of immune cell infiltration occurs. High degree of immune cell infiltration is interferon-gamma-related, and is associated with poor survival. It allows for two-tier stratification, which is prognostically less efficient than a three-tier one. CNA model with three risk-groups where immune cell infiltration impacts only some subgroups led to the best prognostic stratification.