Tabata Y, et al. - The purpose of this study was to determine if DJ-1 expression serves as a biomarker for patients with invasive extrahepatic cholangiocarcinoma (EHCC) who undergo surgical resection with curative intent. It was shown that negative immunohistochemical (IHC) staining for DJ-1 in cytoplasm is an independent risk factor for adverse prognosis. The IHC staining pattern and serum level of DJ-1 aids in the prediction of prognosis and metastasis, respectively, in patients with invasive EHCC.