Koshiol J, et al. - Given that gallbladder dysplasia can progress to cancer and could be associated with increased cancer risk at other biliary tract sites, researchers intended to explore data on the frequency and distribution of gallbladder dysplasia. In order to review 140 totally sampled consecutive cholecystectomy specimens from Chilean women, an expert pathology group used consensus criteria. They found that low-grade dysplasia (LGD) was typically very focal and would often be missed in routine practice. Findings revealed that the predominance of LGD in the fundus provided etiologic insight, supporting the contribution of gallstones and chronic inflammation.