Xiang P, Zhang X, Liu D, et al. - In this study of retrospectively included patients with primary soft-tissue sarcomas (STS) undergoing MRI before iatrogenic procedures, researchers focused on the role of intratumoral heterogeneity on MRI evaluated by histogram analysis in discriminating STS of varied grades. Using Federation Nationale des Centres de Lutte Contre le Cancer grading system, they defined histologic grades. By dividing mean signal intensity (SI) of contralateral/near unaffected muscles, they normalized T1WI and T2WI. For normalizing contrast-enhanced T1WI, they calculated enhancement ratio (ER) map as (SI_post-SI_pre)/SI_pre×100, where SI_pre and SI_post represent SI of each pixel prior to and following enhancement. Based on the findings, they concluded that discrimination of STS of different grades is possible via intratumoral heterogeneity on MRI quantitatively showed by histogram parameters. Skewness and kurtosis on ER maps displayed the capacity.